Middlesex (original) Jeffrey Eugenides

The astonishing tale of a gene that passes down through three generations of a Greek-American family and flowers in the body of a teenage girl.

In the spring of 1974, Calliope Stephanides, a student at a girls' school in Grosse Pointe, finds herself drawn to a chain-smoking, strawberry blond classmate with a gift for acting. The passion that furtively develops between them--along with Callie's failure to develop--leads Callie to suspect that she is not like other girls. In fact, she is not really a girl at all.